HER2 Regulates The Mammary Stem/Progenitor Cell Population Driving Tumorigenesis

The cancer stem cell hypothesis proposes that cancers arise in stem/progenitor cells through disregulation of self-renewal pathways generating tumors, which are driven by a component of 'tumor-initiating cells' retaining stem cell properties. The HER2 gene is amplified in 2030% of human breast cance...

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