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3-Methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression
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Laboratory Investigation
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November 05, 2009
Background and purpose: There is a strong correlation between cytochrome P450 (P450)-dependent arachidonic acid metabolism and the pathogenesis of cardiac hypertrophy. Several aryl hydrocarbon receptor (AhR) ligands were found to alter P450-dependent arachidonic acid metabolism. Here, we have invest...
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